Total Solution to Bone Marrow Aspiration & Autograft
Marrow Cellution™ bone graft kits provide high quality bone marrow aspirate and cancellous bone autograft, collected from numerous sites within the marrow space – achieving the gold standard of autograft in a minimally invasive manner.
Revolutionary Design - Aspirate to Application
Marrow Cellution™ has been designed to alter the fluid dynamics of a conventional bone marrow aspiration in a way that maximizes stem and progenitor cell recovery while minimizing peripheral blood infiltration. Because fluid under force follows the path of least resistance, trocar needles with side ports aspirate primarily through the distal end of the cannula. This leads to excessive blood collection, requiring additional manipulation, i.e. centrifugation or chemical separation in a laboratory.
Marrow Cellution™ accesses aspirate flow collected exclusively laterally as the tip of the aspiration cannula is closed allowing marrow collection perpendicular to and around the channel created by the device. It incorporates technology to precisely reposition the retrieval cannula within the marrow space after each aspiration. These features achieve a clinicians' desire for a single entry point.
Fenestrated Trocar (Marrow Cellutions™)
Minimally Invasive Collection of Autologous Cancellous Graft Material
Harvesting intact cancellous bone cores without disrupting the highly-organized living tissue is superior to transplanting pieces of bone. Intact grafts maintain the micro-vascular network within the graft promoting bone callus formation/remodeling and do not exhibit extensive resorption ¹ ².
Using the Marrow Cellution™ Graft Delivery Syringe and the Marrow Cellution™ Bone Core Harvest Device, the clinician can create a combination graft of a vascularized intact bone core in the center of the graft surrounded by allogeneic, autologous or synthetic bone chips hydrated with cellular marrow aspirate.
How It Works
Both the Marrow Cellutions Aspiration and Percutaneous Bone Graft kits are designed to operate in a minimally invasive, single point of entry application.
Bone marrow aspirate (BMA) is an autologous biologic derived from a patient’s own bone marrow. BMA is high in hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), which are known to be vital to biological processes such as the regeneration of tissue—including cartilage, muscle, marrow, tendons, ligaments and connective tissue—as well as bone formation ³ ⁴ ⁵ ⁶.
Bone Marrow Aspirate
Bleuming SA, et al. Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer Res. 2007 Sep 1;67(17):8149-55.
Ostrup LT, et al. Distant transfer of a free, living bone graft by microvascular anastomoses. An experimental study. Plast Reconstr Surg. 1974 Sep;54(3):274-85.
Matsumoto T, et al., “Therapeutic Potential of Vasculogenesis and Osteogenesis Promoted by Peripheral Blood CD34-Positive Cells for Functional Bone Healing.” The American Journal of Pathology 2006; 169 (4): 1440–1457.
Matsumoto T, et al., “Fracture Induced Mobilization and Incorporation of Bone MarrowDerived Endothelial Progenitor Cells for Bone Healing.” Journal of Cellular Physiology 2008; 215 (1): 234–242.
Mifune Y, et al., “Local Delivery of Granulocyte Colony Stimulating Factor-Mobilized CD34- Positive Progenitor Cells Using Bioscaffold for Modality of Unhealing Bone Fracture.” Stem Cells 2008; 26 (6): 1395–1405.
Tondreau T, et al., “Mesenchymal Stem Cells Derived From CD133-Positive Cells in Mobilized Peripheral Blood and Cord Blood: Proliferation, Oct4 Expression, and Plasticity.” Stem Cells 2005; 23 (8): 1105–1112.